 Anemia Of Chronic Disease - Kidney Liver Disease - Sidroblasts And Hemolysis
For Previous Discussion, Please Click The Following Link:
Anemia Of Chronic Disease: As the name suggests, this is the anemia due to certain disease, which becomes responsible for decrease in RBCs concentration in the blood and or breaking down of RBCs. Following is the brief detail for the types of Anemia of Chronic Disease; Anemia Of Chronic Disease: Jesa ke name se zahir hai kay ye anemia kuch daaemi bemaryon se hota hai jin ki wajah se RBCs ki miqdaar blood main kam hojati hai ya phir RBCs break hone lagte hain. Zail main Chronic Disease Ke Anemia Ki Types byan ki jarahe hai. Anemia Of Chronic Disease Due to Kidney Failure: Kidneys are responsible for the cleaning of waste from the body. Another important function of Kidneys is to produce blood-generating hormone known as Erythropoietin. This hormone is secreted by the kidneys and act on marrow to enhance the RBCs (Red Blood Cell) synthesis. Unfortunately, at the time of kidney failure usually in advanced kidney disease, the Erythropoietin doesn't produce in sufficient amount to cope with the needs of RBCs production. Therefore, a person develops anemia.
The basic test of blood CBC reveals the picture of anemia of chronic disease if present. In that case, it would become necessary to evaluate the cause of Anemia due to Chronic Disease. Kidney functions are tested via different blood tests like Serum Creatinine, Urea, phosphate etc. Along with that, urine analysis and collection of urine for 24 hours Urinary Creatinine and albumin would reveal the presence and absence of kidney failure and at which stage this failure is existing. Ultrasound and biopsy could also be needed in different cases. In case of Anemia due to Kidney failure Along with iron, Erythropoietin is given at regular interval of time. Full case evaluation is necessary before starting the Erythropoietin since it is a hazardous drug, however; it could be given when advantages overrides the demerits. Erythropoietin is also effective in anemia due to cancers and other inflammatory conditions like Rheumatoid Arthritis. Erythropoietin may needs sessions of dialysis for good response and it is very expensive as well.
Anemia Of Chronic Disease Due to Kidney Failure: Kidneys ka kaam hai jism ka waste kharij kerna. Iske alawa kidneys ka ek aur important function ye hai ke ye Hormone Erythropoietin secrete kerti hain jo blood ko generate kerta hai. Ye hormone kidneys secrete kerti hin jo marrow per act kerkay Red Blood Cell ki production ko berdhata hai. Bad Qismati se Kidney failure ki surat main, amoman advanced kidney disease ki surat main, Erythropoieten makhsoos miqdaar main paida nahi hota ke wo RBCs ki paidawaar ki zarooraton ko pora kersake. Isi leye ek shaks ko anemia hojata hai.
Blood ka bunayadi test CBC batasakta hai ki Anemia Of Chronic Disease present hai ya nahi. Is surat main Anemia Of Chronic Disease ki wajah ko janna zaroori hota hai. Kidneys ke functions ki janch mukhtalif blood tests se ki jati hai jin main Serum Creatinine, Urea aur phosphate waghaira shamil hain. Is ke saath saath peshaab ke tests masalan 24 hours Collection of Urine for Creatinine Clearance and albumin aur Urine DR waghaira. In tests ki madad se ye pata chalta hai ke aya Kidney disease hai aur agar hai to kis stage per hai. Mukhtalif cases mian Kidneys ka Ultrasound ya Biopsy bhi darkaar hoti hai. Kidney failure ki surat main Iron ke saath saath Erythropoietin regular interval per lagaya jata hai. Erythropoietin shuru kerne se pehle pore case ki janch ki jati hai kunke Erythropoiten ek muzir dawa hai lekin isko daina un cases main na guzeer hojata hai jab fawaid nuqsanaat per haawi hojaien. Erythropoitein cancer aur dosri inflammatory conditions jaise Rheumatoid Arthritis wagaira kay anemia main bhe dya jata hai. Erythropoitein kay ache asraat haasil kerne kayleye Dialysis ke sessions ki zaroorat hosakti hai taham Erythropoitein ek mehnga ilaj hai.
Anemia Of Chronic Disease – Other Conditions Anemia due to chronic disease could also develop due to other conditions like marrow inadequacy or failure, chronic liver disease, Thyroid disease and chronic infections. In such cases treating the cause would brings about the improvement in the Hemoglobin level and hence decrease the level of anemia. Anemia Of Chronic Disease – Other Conditions Anemia of chronic disease deegar conditions jaisay marrow ki adam karkardagi or marrow failure, Jigar ki daaimi kharabi, Thyroid diseases aur daeemi infections waghaira se bhi hosakta hai. In conditions main beemari ka cause talash kerke Hemoglobin ko improve kia jasakta hai aur istarhan se anemia ke level main kami aasakti hai. Anemia Due To Sidroblasts Sidroblasts are abnormal Red Blood Cells produced in the bone marrow. Due to abnormal shape, they are easily broken up liberating iron stored in Them. Due to the break down of Sidroblasts, which accounts for the major number of Red Blood Cells population in the blood, the Hemoglobin concentration goes down and hence the patient develops anemia. Due to the massive destruction of Red Blood Cells, iron is accumulated in the body and hence the patient develops iron overload. Usually the patient develops no symptoms besides the anemia symptoms. Bone marrow examination reveals problems of RBCs production. Blood transfusion is occasionally required in case of severe anemia. Bone marrow transplantation would be the final option in life threatening conditions. Anemia Due To Sidroblasts: Sidroblasts marrow main abnormal Red Blood Cells kay paida hone ki wajah se bante hain. Apne abnormal shape ki wajah se ye abnormal RBCs aasani se toot jatay hain aur iron liberate kertay hain. Sidroblasts kay tootne ki wajah se joke ziada tar sidroblasts per mushtamil hote hain Hemoglobin concentration kam hojati hai aue anemia hojata hai. RBCs ki baday paimanay per tootnay kay amal se Iron body main jama hojata hai aur mareez ko Iron over load hojata hai. Amoman mareez ko koi alamat ya shikayat zahir nahi hoti aur agar hoti hai to wo sirf anemia ki alamaat hoti hain. Bone marrow examination se RBCs production ka masala saamne aajata hai.Blood transfusion ki shaazo nadir hi zaroorat padti hai aur blood transfusion severe anemia main hi kia jata hai. Jaan laiwa conditions main Bone Marrow Transplantation akhri kaarwai hoti hai.
Anemia Due To Hemolysis:
In Hemolysis, the Red Cells break down early. The normal life span of a Red Blood Cell is 120 days and after that a new Red Blood Cell take the place of old one. Due to this early breaking of Red Blood Cells, Hemoglobin and Red Blood Cell, concentration falls In blood. Usually bone marrow replaces the lost Red Blood Cells so quickly that the hemoglobin doesn't fall more. However; once the capacity of bone marrow to produce enough Red Blood Cells to over come the loses is diminished, then the symptoms of anemia starts to appear. There are different causes of this Hemolysis including the membrane defects of Red Blood Cells, Hereditary problems, Autoimmune conditions, infections, burns etc. Reticulocyte count is found high in case of Hemolysis that would give the clue for diagnosis. Treatment is to target the cause of Hemolysis and giving medication accordingly. Autoimmune conditions may need steroids, and infections should need appropriate antibiotics. Anemia Due To Hemolysis:
Hemolysis main, Red Cells bohat jald toot jatay hain. Red Blood Cell ki normal life 120 din hai aur iske baad is ki jaga dosra naya Red Blood Cell ajata hai. Is juld Red Blood Cells kay break hone se blood main Red Blood Cells aur Hemoglobin ki concentration ya miqdaar kam hojati hai. Amoman Bone marrow zayan hone wale Red Cells ko itne jaldi replace kerdayta hai ke Hemoglobin kam nahi hota. Lekin agar bone marrow ki Red Blood Cells produce kernay ki capacity kam hojaiy to anemia ki symptoms zahir hona shuru hojati hain.
Hemolysis ki kayi ek wajohaat hain jin main Red Cells ki membrane ka defect, moorsi masayl, Khud-mudafiyati halatain, infections, burns waghaira shamil hain. Hemolysis ki mojoodgi main Reticulocyte count high hojata hai aur is tarhan Reticulocyte count ki janch se Hemolysis ki tashkhees main aasani hoti hai.
Hemolysis ki treatment Hemolysis kay cause per munhassir hai aur adwyat us ke mutabiq hi deejati hain. Khud-mudafyati halat main Steriods ka istemal aur infection ki surat main antibiotics di jati hain.
Continued..............
Members are requested please not to post comments. However they may ask related questions on anemia.
|
